ZHU, Bingdong
Professor, Head of Institute of Pathogen Biology, School of Basic Medical Sciences, Lanzhou University.
Email address: bdzhu@lzu.edu.cn
RESEARCH INTERESTS
1. Tuberculosis subunit vaccine and vaccine-induced immune memory
2. Tuberculosis immunopathology, especially on immune exhaustion
3. Tumor immunology and glycolysis
Selected publications:
2. Li F, Liu X, Niu H, Lv W, Han X, Zhang Y, Zhu B*. Persistent stimulation with Mycobacterium tuberculosis antigen impairs the proliferation and transcriptional program of hematopoietic cells in bone marrow. Mol Immunol. 2019 Aug;112:115-122. doi: 10.1016/j.molimm.2019.05.001.
3. Bai C, He J, Niu H, Hu L, Luo Y, Liu X, Peng L, Zhu B*. Prolonged intervals during Mycobacterium tuberculosis subunit vaccine boosting contributes to eliciting immunity mediated by central memory-like T cells. Tuberculosis (Edinb). 2018 May;110:104-111. doi: 10.1016/j.tube.2018.04.006. Epub 2018 Apr 24. PubMed PMID: 29779765.
4. Zhu B*, Dockrell HM, Ottenhoff THM, Evans TG, Zhang Y. Tuberculosis vaccines: Opportunities and challenges. Respirology. 2018 Apr;23(4):359-368. doi:10.1111/resp.13245. Epub 2018 Jan 17. Review. PubMed PMID: 29341430.
5. Liu X, Peng J, Hu L, Luo Y, Niu H, Bai C, Wang Q, Li F, Yu H, Wang B, Chen H, Guo M, Zhu B*. A multistage Mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis. Hum Vaccin Immunother. 2016;12(7):1670-7. PubMed PMID: 26901244.
6. Liu X, Da Z, Wang Y, Niu H, Li R, Yu H, He S, Guo M, Wang Y, Luo Y, Ma X, Zhu B*. A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice. Vaccine. 2016;34(11):1370-8. PubMed PMID: 26845736.
7. Luo Y, Ma X, Liu X, Lu X, Niu H, Yu H, Bai C, Peng J, Xian Q, Wang Y, Zhu B*. IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization. Int Immunol. 2016;28(2):77-85.
8. Niu H, Peng J, Bai C, Liu X, Hu L, Luo Y, Wang B, Zhang Y, Chen J, Yu H, Xian Q, Zhu B*. Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice. PLoS One. 2015 Jun 22;10(6):e0130641.
9. Liu X, Wang D, Liu H, Feng Y, Zhu T, Zhang L, Zhu B*, Zhang Y*. Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance. Cell Cycle. 2014;13(11):1702-7.
10. Xin Q, Niu H, Li Z, Zhang G, Hu L, Wang B, Li J, Yu H, Liu W, Wang Y, Da Z, Li R, Xian Q, Wang Y, Zhang Y, Jing T, Ma X, Zhu B*. Subunit vaccine consisting of multi-stage antigens has high protective efficacy against Mycobacterium tuberculosis infection in mice. PLoS One. 2013 Aug 15;8(8):e72745.
