RESEARCH INTERESTS
      Medical Genetics components of major polygenic disorders, including gastric cancer，breast cancer, congenital heart disease, rheumatoid, diabetes, and hypertension in Northwest China and Qinghai-Tibet Plateau region.

Human population genetics, focusing on the origin, migration and evolution of ethnic groups from Northwest China and Qinghai-Tibet Plateau region.

Education/Training:
       2006.06 to the present: Professor, School of Basic Medical Science, Lanzhou University
       2003.05 to 2006.05: Associate Professor, School of Life Science, Lanzhou University
       2001.08 to 2003.05: postdoctoral in Institute of Genetics and Developmental Biology, Chinese Academy of Science

2009.04 to 2010.4: Visiting Fellow in Leverhulme Centre for Human Evolutionary Studies, University of Cambridge, UK

 

Awards&Honors:
      The national outstanding scientific and technological personnel, 2014

New Century Excellent Talents in University, from Ministry of Education of P.R.China, 2005

Gansu Provincial Science and Technology Awards for High Education Institute, from the Education Bureau of Gansu Province, China, 2014

Chinese medical science and technology prize, from Chinese Medical Association, China, 2013

Gansu Provincial Science and Technology Outstanding Award for medical Sciences, from the Health Bureau of Gansu Province, China, 2012

Gansu Provincial Science and Technology Awards, from the Government of Gansu Province, China, 2012

Gansu Provincial Science and Technology Awards, from the Government of Gansu Province, China, 2008

Gansu Provincial Science and Technology Awards for High Education Institute, from the Education Bureau of Gansu Province, China, 2007

 Gansu Provincial Teaching Awards for High Education Institute, from the Education Bureau of Gansu Province, China, 2007

Gansu Provincial Science and Technology Awards for medicine, from the Health Bureau of Gansu Province, China, 2006
Projects: 

1.      Studies on effect of susceptibility of congenital heart disease from interaction between plateau environmental factors and environmental response gene SESN2, grant from National Natural Science Foundation of China（31670379）;

2.      Do languages and genes correlate? - A case study in Northwestern China，grant from The French National Research Agency（ANR-12-BSH2-0004-01）

3.      International Cooperative Research of Translational Medicine for Congenital Heart Defects, grant from national International Cooperative Research Program（2011DFA33120）

4.      Genetic studies on heavy ion radiotherapy for Chinese pepole, grant from State Key Development Program of Basic Research of China(2010CB834201);

5.      Genetic studies on ventricular septal defect among Chinese population, grant from State Key Development Program of Basic Research of China (2010CB529500)

Publications:

2018 Jinduo Zhang，Gang Su，Zengwei Tang，Li Wang，Wenkang Fu，Sheng Zhao，Yongjiang Ba，Bing Bai，Ping Yue，Yanyan Lin，Zhongtian Bai， Jinjing Hu，Wenbo Meng*，Liang Qiao，Xun Li，Xiaodong Xie* Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front. Physiol., (3): doi.org/10.3389/fphys.2018.00234

2017 Yi Li, Zhengyi Zhang, Xiangnan Zhou, Rui Li, Yan Cheng, Bo Shang, Yu Han, Bin Liu, Xiaodong Xie*.  Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness. Circulation Journal, doi.org/10.1253/circj.CJ-17-0022

2017 XieHan-hui, LiJiong, Pei-qiangLi, Zhang An-an, LiYi, Wang Yan-zhen, Xie Ding-xiong, Xie Xiao-dong* . A Genetic Variant in a Homocysteine Metabolic Gene that Increases the Risk of Congenital Cardiac Septal Defects in Han Chinese Populations. IUBMB Life, 69(9):700–705

2016 Lu Guo, Caixia Zhang, Jinghong Zhu, Yuqin Yang, Jianfa Lan, Gang Su, Xiaodong Xie*. Proteomic identification of predictive tissue biomarkers of sensitive to neoadjuvant chemotherapy in squamous cervical cancer. Life Sciences, 151(4): 102-108

2016 Zheng-Yi Zhang, Yi Li, Rui Li, An-An Zhang, Bo Shang, Jing Yu, Xiao-Dong Xie. Tetrahydrobiopterin Protects against Radiation？induced Growth Inhibition in H9c2 Cardiomyocytes. Chinese Medical Journal, 129 (11): 2733-2740

2015 Lu Guo, Hua Wu, Jinghong Zhu, Caixia Zhang, Jianxiu Ma, Jianfa Lan, Xiaodong Xie*. Genetic variations in the PI3K/AKT pathway predict platinum-based neoadjuvant chemotherapeutic sensitivity in squamous cervical cancer. Life Sciences,  143:217-224

2015 Hua Wu, Yuan-hui Gu, Li Wei, Tian-kang Guo, Yong Zhao, Gang Su, Jiong Li, Xiao-dong Xie*.  Association of Romo1 gene genetic polymorphisms with risk of gastric cancer in Northwestern Chinese population. Pathol. Oncol. Res, 21:581-587

2015 Zhenchang Zhang, Gang Su, Jia Guo, Jiong Li, Hua Wu, Xiaodong Xie*. Pooled Genetic Analysis Reveals an Association of SNPs of Only a Few Genes with Risk Predisposition to Ischemic Stroke in a Chinese Population. IUBMB Life, 67(3):170-174

2014 Zhenchang Zhang, Jia Guo, Gang Su, Jiong Li, Hua Wu, Xiaodong Xie*. Evaluation of the Quality of Guidelines for Myasthenia Gravis with the AGREE II Instrument. PLos one, 9(11): 1-8 e111796

2014  Jinpeng He, Junrui Hua, Nan Ding, Shuai Xu, Rui Sun, Guangming Zhou, Xiaodong Xie*, Jufang Wang*. Modulation of microRNAs by ionizing radiation in human gastric cancer. ONCOLOGY REPORTS 32: 787-793