Name: Jian Han

Professional Title：Full Professor，

Supervisor of Master

Office: Jingcheng Building, Lanzhou University

E-mail: hanj@lzu.edu.cn

Research Interests:

1.The mechanisms of formation, prevention and control of bacterial persister.

2. Pathogenesis and drug resistance of Helicobacter pylori.

Education/Training:

1993  Lanzhou Medical College  B.S.

2003  Lanzhou Medical College  Master degree in Medicine

2014  Lanzhou University  Ph.D. in Science

Awards&Honors: 

1. First Grade Prize, Teaching Achievement Award of Gansu Province, 2015

2. Second Grade Prize, Science and Technology Progress Award of Gansu Province, 2008

Projects:

1. NSFC(81571952)  Regulating Mechanisms of Transcription Factor NWMN_0037 on Staphylococcus aureus Persisters Formation, Virulence and Metabolism. 2016.1-2019.12

2. Natural Science Foundation of Gansu Province (0803RJZA073): Effects of High Nickel Environment in Hexi Corridor on Pathogenicity and Genetic Characteristics of Urease of Helicobacter pylori, 2009.1-2010.12

Publications:

1. Yuanyuan Xu, Li Wang, Xudong Sun, Xiaogang Xu, Ting Hu, Bo Dong, Tao Jing, Jian Han*, Ying Zhang*. Fluorescence Reporter in Staphylococcus aureus as a Useful Tool for Studying L-forms and Virulence. Jundishapur J Microbiol. 2017; 10(9):e57238.

2. Jinhua Zhang, Xudong Sun, Jiemin Wang, Fuhua Zhang, Xiaohua Li, Jian Han*. Association of the IL-1RN Variable Number of Tandem Repeat Polymorphism and Helicobacter pylori Infection: A Meta-Analysis. PLoS One. 2017;12(4): e0175052.

3. Tao Xu, Jian Han, Jia Zhang, Jiazhen Chen, Nan Wu, Wenhong Zhang* and Ying Zhang*. Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA. Front Microbiol. 2016;7:1625. eCollection.

4. Sun X, Xu Y, Wang L, Zhang F, Zhang J, Fu X, Jing T, Han J*. Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis. PLoS One. 2016;11(1):e0147410.

5. Sun X, Xu Y, Zhang F, Jing T, Han J*, Zhang J*. Association between the IL1B -31C > T polymorphism and Helicobacter pylori infection in Asian and Latin American population: A meta-analysis. Microb Pathog. 2015;86:45-52.

6. Han J, Bao G, Zhang D, Gao P, Wu T, Craig P, Giraudoux P, Chen X, Xin Q, He L, Chen G, Jing T. A Newly Discovered Epidemic Area of Echinococcus multilocularis in West Gansu Province in China. PLoS One. 2015;10(7):e0132731.

7. Han J, Shi W, Xu X, Wang S, Zhang S, He L, Sun X, Zhang Y. Conditions and mutations affecting Staphylococcus aureus L-form formation. Microbiology. 2015; 161: 57–66

8. Han J, He L, Shi W, Xu X, Wang S, Zhang S, Zhang Y. Glycerol Uptake Is Important for L-Form Formation and Persistence in Staphylococcus aureus. PLoS One. 2014;9(9):e108325.

9. Zhao Y, Li Y, Han J, Liu T, Guan Q, Zhao P, Guo L, Liu K, He D. Helicobacter pylori enhances CIP2A expression and cell proliferation via JNK2/ATF2 signaling in human gastric cancer cells. Int J Mol Med. 2014;33(3):703-10

10. Liu H, Yao X, Wang C, Han J. In silico identification of the potential drug resistance sites over 2009 influenza A (H1N1) virus neuraminidase. Mol Pharm. 2010;7(3):894-904