Name: Li Wenguang

Professional Title：Full Professor，

                    Master’s Supervisor

mail: liwg@lzu.edu.cn

Research Interests: pharmacology of antineoplastic agents;  pharmacology of new drugs

 

Education/Training: 

2006   Life Science School of Lanzhou University Ph.D in Cell Biology

1991   Dept. of Pharmacology of Lanzhou Medical College  MA in Pharmacology

1988   Dept. of Clinical Medicine of Lanzhou Medical College  BA in Clinical Medicine

 

Awards&Honors:

2002   obtained The ninth Gansu Youth Teacher Award

2009  obtained the Second levels of leading talents in Gansu Province

2006  Mechanisms of Proanthocyanidin from Grape Seeds in both Potentiating Anti-tumor Activity and Reducing Toxicity of Doxorubicin obtained the second prize of Gansu Provincial Natural Science

2006  Preclinical study of grape seed extract via enteral drug delivery system obtained the second Gansu Provincial prize  for Progress in Science and Technology

2008  Pharmacology, toxicology and mechanism of different protein drugs in tissue repair and inflammator obtained the second Gansu Provincial prize for Progress in Science and Technology

2001  Study on the mechanism of myocardial protection and antiarrhythmic effect of IHC-66 obtained the third Gansu Provincial prize for Progress in Science and Technology

2016  Study on the mechanism of ortho aminophenol norepinephrine toxin in the treatment of osteosarcoma obtained the third Shanxi Provincial prize for Progress in Science and Technology

 

ProvinceProjects:

NNSFC    Regulatory effect of Shengji Yuhong ointment on dermal pluripotent stem cells in deep II burned rats and gene chip analysis. 2012.1-2015.12

Gansu Province Natural Science Research Fund  The mechanisms of　Isoliquiritigenin on antitumor angiogenesis，2012.1-2014.1

Gansu Province Natural Science Research Fund  The mechanisms of　rare earth complexes anti-tumor activity，2008.1-2009.12

Lanzhou science and technology plan Fund  Anti-osteosarcoma effects and mechanisms of New podophyllotoxin derivatives，2007.1-2008.12

Gansu Province Natural Science Research Fund  Establishment of antiviral screening model and antiviral Chinese Medicine. 2004.7-2006.12

Publications: （限10项）

1.YuanYuan LIU, Jing GAO, ShuangSheng HUANG, LaMei HU, ZhiQiang WANG, ZheYuan WANG, Xiao CHEN, XiaoYu ZHANG and WenGuang LI*.  4？isothiocyanate？2, 2, 6, 6？tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation. Oncol. Lett. 2016 (12): 2828-2834. (SCI, IF₂₀₁₅ = 1.80) （*Corresponding author）

2.WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941–949. (SCI, IF₂₀₁₃ = 2.033)

3.LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 2002; 23(8): 727–732. (SCI, IF₂₀₁₃ = 2.354)

4.LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI, IF₂₀₁₃ = 2.354)

5.Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI*. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008；60(2): 179–188. (SCI, IF₂₀₁₃ = 2.033) （*Corresponding author）

6.XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432–438. (SCI, IF₂₀₁₃ = 0.962)

7.XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247–1257. (SCI, IF₂₀₁₃ = 2.417)

8.XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309–318. (SCI, IF₂₀₁₃ = 1.556)

9.Cuilan Hou, Wenguang Li, Zengyou Li, Jing Gao, Zhenjie Chen, Xiqiong Zhao,Yaya Yang, Xiaoyu Zhang and Yong Song. Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism. Oxid. Med. Cell Longev. Volume 2017, Article ID 1379430, 11 pages https://doi.org/10.1155/2017/1379430

10.Qian Yan, Ruxia Li, Aiyi Xin, Yin Han, Yanxia Zhang, Junxi Liu, Wenguang Li, Duolong Di. Design, synthesis, and anticancer properties of isocorydine derivatives. Bioorganic & Medicinal Chemistry 25 (2017) 6542–6553