Name: Yi-Ping HOU
Professional Title：Full Professor, Ph. D. & M.D. Supervisor, Director of Department of Neuroscience.
Office: 106 Jingcheng Building
E-mail: houyiping@lzu.edu.cn
Research Interests: Sleep-wake regulation and sleep diseases, mechanism and neural circuits of olfaction, mechanism of botulinum toxin in clinic application, physiology and pharmacology of neuropeptides.
Education/Training:
1978-1983 Undergraduate, Faculty of Clinical Medicine, Lanzhou Medical College, Bachelor of Medicine.
1983-1989 Teaching Assistant, Department of Anatomy, Lanzhou Medical College.
1985-1988 Postgraduate, Department of Anatomy, Lanzhou Medical College. Master Degree of Medicine. Supervisor: Prof. Jingzhong GONG.
1989-1991 Assistant Professor, Department of Anatomy, Lanzhou Medical College.
1992-1993 Study abroad, Faculty of Science, Claude Bernard University, Lyon France. Supervisor: Dr. L. Astic.
1993-1995 Post-doctoral, Faculty of Medicine, Claude Bernard University, Lyon, France. Supervisor: Prof. M. Jouvet and Dr. JS. Lin.
1995-1998 Associate Professor, Department of Anatomy, Lanzhou Medical College.
1999-2000 Visiting Scholar, McGill Universit, Montreal, Canada. Supervisor: Prof. B E. Jones；
1999-2004 Full Professor, Lanzhou Medical College.
2004- Professor, Ph.D & M.D. Supervisor, Director of Department of Neuroscience, School of Basic Medical Sciences, Lanzhou University.
Awards & Honors:
Honored with special post allowance of state council (2008); Award of Gansu virtue pacesetter (2008); Award of outstanding teacher in Gansu colleges and universities (2007); Award of excellent teacher of Baosteel (2007); First person to “333 talent engineering in science and technology” Gansu province (1998); Gansu best youth (1997); Pace-setter in the new Long March of Gansu province (1997); Leader in cross-century disciplines of Gansu colleges and universities (1995).
Projects:
1. NSFC: Sleep-wake development and the regulation and role of REM sleep in early life（81771426，2018-2021）
2. NSFC: Regulative effects and mechanism of galanin and its receptors in sleep and sleep disorder induced by emotional disturbances（81471347，2015-2018）
3. NSFC: Adolescent mental health and disease（81581260433，2015.10-2015.12）
4.
NSFC: The mechanism involvment in Neuropeptide S and its receptor system modulates sleep-wake states through activation of post-hypothalamic
histaminergic and orexinergic neurons（81171254，2012-2015）
5. Beijing Key Laboratory of Major Brain Diseases: The effects and mechanism of Neuropeptide S and galanin on depression-induced sleep disorders and anti-depression（2012-2014）
6. NSFC: The role of Neuropeptide S and its receptor in sleep-wake states (81071076，2011.01-2011.12）
7. MSTC (Key National S &T Program): Key technology and methods in several peptide synthesis and modify (2009ZX09503-017，2009-2010), sub-project.
8. NSFC: Role of posterior hypothalamic histaminergic, GABAergic and SP neurons in sleep-wake cycle（30670677，2007-2009）
9. Gansu Provincial Sci. & Tec. Department: BTX enhances cellular destroy of anti-cancer of chemical drugs via increasing local blood perfusion（090NKCA112，2009-2012）.
Publications:
1. Xie JF, Shao YF, Wang HL, Wang C, Cui GF, Kong XP, Wang LX, Chen YN, Cong CY, Chen HL and Hou YP*. Neuropeptide S counteracts paradoxical sleep deprivation-induced anxiety-like behavior and sleep disturbances. Front Cell Neurosci 2018; 12:64,1-15.
2. Xie JF, Fan K, Wang, C, Xie P, Hou M, Xin, L, Cui GF, Wang LX, Shao YF*, Hou YP*. Inactivation of the tuberomammillary nucleus by GABAA receptor agonist promotes slow wave sleep in freely moving rats and histamine-treated rats. Neurochem Res 2017; 42:2314–2325.
3. Kong XP, Wang C, Xie JF, Zhao P, Dai LR, Shao YF*, Lin JS*, Hou YP*. Neuropeptide S reduces propofol- or ketamine- induced slow wave states through activation of cognate receptors in the rats. Neuropeptides 2017; 63:59-66.
4. Shao YF, Wang C, Xie JF, Kong XP, Xin L, Dong CY, Li J, Ren WT, Hou YP*. Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex. Brain Struct Funct 2016;221:3327-3336.
5. Hou M, Xie JF, Kong XP, Zhang Y, Shao YF, Wang C, Ren WT, Cui GF, Xin L, Hou YP*. Acupoint injection of onabotulinumtoxin A for migraines. Toxins 2015; 7(11): 4442-4454.
6. Shao YF, Xie JF, Ren YX, Wang C, Kong XP, Zong XJ, Fan LL, Hou YP*. The inhibitory effect of botulinum toxin type A on rat pyloric smooth muscle contractile response to substance P in vitro. Toxins 2015; 7(10): 4143-4156.
7. Shao YF, Zhao P, Dong CY, Li J, Kong XP, Wang HL, Dai LR, Hou YP*. Neuropeptide S facilitates mice olfactory function through activation of cognate receptor-expressing neurons in the olfactory cortex. PLoS One 2013; 8(4):e62089.
8. Zhao P, Shao YF, Zhang M, Fan K, Kong XP, Wang R, Hou YP*. Neuropeptide S promotes wakefulness through activation of the posterior hypothalamic histaminergic and orexinergic neurons. Neuroscience 2012; 207:218-226.
9. Hou YP, Manns ID, Jones BE. Immunostaining of choliergic pontomesencephallic neurons for α1 versus α2 adrenergic receptors suggests different sleep-wake state activities and roles. Neuroscience 2002; 114 (3):517-521.
10. Hou YP, Lin JS. Effects of modafinil and amphetamine on sleep-wake cycle after sleep deprivation in cats. Acta Pharmacol Sin 1999; 20(9):813-818.
