Name: Yu Luo

Professional Title：Associate Professor

Office:  Lanzhou University

E-mail: luoy@lzu.edu.cn

Research Interests:  Alzheimer’s Disease

 

Education/Training: 

2001, Hebei Medical University, Bachelor of Medicine

2006, Lanzhou University, Master of Medicine

2013, Tongji Medical College, Huazhong University of Science and Technology, Doctor of Medicine

Projects: 

The effects of Hydroxysafflor Yellow A on chronic mild stress-induced memory impairments in mice, 2015.7.1-2017.06.30

Differential expression of proteome in brain of acute stress animal model, 2015.5.1-2019.4.30

Publications:

【1】Luo Y, Nie YJ, Shi HR, Ni ZF, Wang Q, Wang JZ, Liu GP .PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B. Biochim Biophys Acta. 2013 May;1833(5):1235-43.

【2】 Luo Y, Jiang W, Da Z, Wang B, Hu L, Zhang Y, An R, Yu H, Sun H, Tang K, Tang Z, Wang Y, Jing T, Zhu B. Subunit vaccine candidate AMM down-regulated the regulatory T cells and enhanced the protective immunity of BCG on a suitable schedule. Scand J Immunol. 2012 Mar;75(3):293-300.

【3】Luo Y, Wang B, Hu L, Yu H, Da Z, Jiang W, Song N, Qie Y, Wang H, Tang Z, Xian Q, Zhang Y, Zhu B. Fusion protein Ag85B-MPT64(190-198)-Mtb8.4 has higher immunogenicity than Ag85B with capacity to boost BCG-primed immunity against Mycobacterium tuberculosis in mice. Vaccine. 2009 Oct 19;27(44):6179-85. Epub 2009 Aug 25.

【4】Lu Y, Luo Y, He Z, et al. Hydroxysafflor Yellow A Ameliorates Homocysteine-Induced Alzheimer-Like Pathologic Dysfunction and Memory/Synaptic Disorder[J]. Rejuvenation Research, 2013,16(6):446-452.

【5】Li X, Hu Y, Wang Z, Luo Y, Zhang Y, Liu X, Feng Q, Wang Q, Ye K, Liu G, Wang J. Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins. SCI REP-UK 2016;6:24756.

【6】Hu Y, Li XC, Wang ZH, Luo Y, Zhang X, Liu XP, Feng Q, Wang Q, Yue Z, Chen Z, Ye K, Wang JZ, Liu GP. Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial parkin. ONCOTARGET 2016.

【7】Duan DX, Chai GS, Ni ZF, Hu Y, Luo Y, Cheng XS, Chen NN, Wang JZ and Liu GP(2013)Phosphorylation of tau by death-associated protein kinase 1 antagonizes the kinase-induced cell apoptosis.J Alzheimers Dis37, 795-808

【8】Cheng XS, Zhao KP, Jiang X, Du LL, Li XH, Ma ZW, Yao J, Luo Y, Duan DX, Wang JZ and Zhou XW(2013)Nmnat2 attenuates Tau phosphorylation through activation of PP2A.J Alzheimers Dis36, 185-95.