Name: Xin Liu

Professional Title：Associate Professor，

                    Master’s Supervisor

E-mail: liuxinlz@lzu.edu.cn

Research Interests: Rational drug design；Development of biomedicinal peptide；

Computer-aided drug design

Education/Training: 

2005-2010  Lanzhou University  Ph.D. in Biochemistry and Molecular Biology 

2001-2005  Lanzhou University  B.S. in Biological science

 

Awards&Honors: 

 

Projects:  National Natural Science Foundation of China, 21402076, 2015.01-2017.12

 

Publications: （限10项）

1.      Xin Liu1, Yuan Wang1, Yanhong Xing1, Jing Yu, Hong Ji, Ming Kai, Zilong Wang, Dan Wang, Yixin Zhang, Depeng Zhao, and Rui Wang. Design, Synthesis, and Pharmacological Characterization of Novel Endomorphin-1 Analogues as Extremely Potent μ-Opioid Agonists. Journal of Medicinal Chemistry, 2013, 56, 3102-3114.

2.      Xin Liu, Long Zhao, Yuan Wang, Lingyun Mou, Junxian Yang, Yixin Zhang, Dan Wang, Rui Wang. Design, synthesis, and evaluation of new endomorphin analogs with enhanced central antinociception after peripheral administration. Bioorganic & Medicinal Chemistry Letters. 2015, 25:5393- 5397.

3.      Xin Liu, Long Zhao, Yuan Wang, Jingjing Zhou, Dan Wang, Yixin Zhang, Xianghui Zhang, Zhaojuan Wang, Dongxu Yang, Lingyun Mou, and Rui Wang. MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile. ACS Chem. Neurosci., DOI:10.1021/acschemneuro. 7b00097

4.      Yuan Wang1, Yanhong Xing1, Xin Liu1, Hong Ji, Ming Kai, Zongyao Chen, Jing Yu, Depeng Zhao, and Rui Wang. A New Class of Highly Potent and Selective Endomorphin-1 Analogues Containing α-Methylene-β-aminopropanoic Acids (Map). Journal of Medicinal Chemistry, 2012, 55, 6224-6236.

5.      Yuan Wang, Xin Liu, Dan Wang, Junxian Yang, Long Zhao, Jing Yu, Rui Wang*. Endomorphin-1 analogues (MELs) penetrate the bloode brain barrier and exhibit good analgesic effects with minimal side effects. Neuropharmacology，2015, 97, 312-321.

6.      Yuan Wang, Junxian Yang, Xin Liu, Long Zhao, Dongxu Yang, Jingjing Zhou, Dan Wang, Lingyun Mou and Rui Wang. Endomorphin-1 analogs containing α-methyl-β-amino acids exhibit potent analgesic activity after peripheral administration. Organic & Biomolecular Chemistry, 2017, 15, 4951–4955.

7.      Yuan Wang, Jingjing Zhou, Xin Liu, Long Zhao, Zhaojuan Wang, Xianghui Zhang, Kezhou Wang, Linqing Wang, Rui Wang. Structure-constrained endomorphin analogs display differential antinociceptive mechanisms in mice after spinal administration. Peptides. 2017, 91, 40–48.

8.      National invention patent  No.ZL 201110455811.7  

9.      National invention patent  No ZL 201210426909.4