Name：Li Lu

Professional Title：Associate Professor

Office: 415 , Jingcheng Building, Lanzhou University

E-mail: lul@lzu.edu.cn

Research Interests: Role of Astrocytes in central neurodegenerative disease

 

Education/Training: 

2000, Lanzhou Medical College, Bachelor in Medicine,

2004, Lanzhou University, M.M.S. in Pharmacology,

2011,Peking Union Medical College/Chinese Academy of Medical Sciences, M.D. in Pharmacology, 2014, Manchester University, Visiting Scholar

Awards&Honors: 

2013, The Second Class Prize of HuangFuMi of Traditional Chinese Medicine Award in Gansu Province.

2010, The Third Class Prize of HuangFuMi of Traditional Chinese Medicine Award in Gansu Province.

2009, The Second Class Prize of Technological Invention Award in Gansu Province.

Projects: 

1. Project of Key laboratory for innovation and transformation of traditional Chinese medicine in gansu province, ZYFYZH-KJ-2016-004, Research of α- linolenic acid activation TREK - 1 channel to improve learning memory function in SAMP8 mice，2017/01-2018/12

2. Science and Technology Develop Project in Chengguan District，2016-7-8，Regulatory role of P2x7-purinoceptor in adipose stem cells differentiate into schwann cells，2016/07-2018/06

3. Exploration project of central university，lzujbky-2016-65，Regulatory role of P2x7-purinoceptor in adipose stem cells differentiate into schwann cells，2016/01-2017/12

4. Innovation project of Lanzhou science and technology bureau，2015-RC-20，Research of Guiqi polysaccharide iron mixture，2016/01-2018/12

5. Exploration project of central university，lzujbky-2014-144，Research of the TREK - 1 on glutamate pathway to improve learning and memory function of SAMP8 mice，2014/01-2015/12

6. Science and Technology Develop Project in Chengguan District，2011-1-4，Effect of TREK-1 on glutamte cycle between interaction of astrocytes and neurons under ischemia，2012/01-2013/12

7. Exploration project of central university，lzujbky-2011-84，Effect of TREK-1 on glutamte uptake in astrocytes，2011/01-2013/12

8. Natural Science Fund in Gansu Province，1107RJYA046，Regulation role of TREK-1 on astrocytes function under ischemia,2011/01-2013/12

Publications:

1. Zhanjun Ma; Li Lu; Jingjing Yang; Xuexi Wang; Gang Su; Zhuanling Wang; Guohu Chen; Hanmei Sun; Mengyuan Wang; Yang Yang, Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway, European Journal of Pharmacology, 2018, 821: 1~10

2. Li Lu ; Guangru Zhang; Chunli Song; Xuexi Wang; Weina Qian; Zhuanling Wang; Yanan Liu; Sheng Gong; Shuning Zhou, Arachidonic acid has protective effects on oxygen-glucose deprived astrocytes mediated through enhancement of potassium channel TREK-1 activity , Neuroscience Letters, 2017,636: 241~247

3. Li Lu; Lining Yang; Xuexi Wang; Chunli Song; Hong Qin; Yongjie Wu, Synergistic Cytotoxicity of Ampelopsin Sodium and Carboplatin in Human Non-Small Cell Lung Cancer Cell Line SPC-A1 by G(1) Cell Cycle Arrested, Chinese Journal of Integrative Medicine, 2017, 23(2): 125~131

4. Alessandro Faroni; Richard J P Smith; Li Lu; Adam J Reid ,Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium , The EuropeanJournal of Neuroscience, 2016.2, 43(03): 417~430

5. Zhanjun Ma; Xuexi Wang; Gang Su; Jingjing Yang; Yajuan Zhu; Youwei Wu; Jing Li; Li Lu; Long Zeng; Haixia Pei, Proteomic analysis of apoptosis induction by lariciresinol in human HepG2 cells, Chemico-Biological Interactions, 2016, 256: 209~219

6. Li Lu, Weiping Wang, Ying Peng, Jiang Li, Ling Wang, Xiaoliang Wang*, Electrophysiology and pharmacology of tandem domain potassium channel TREK-1 related BDNF synthesis in rat astrocytes, Naunyn Schmiedebergs Arch Pharmacol, 2014, 387(4):303-312

8. Baolai Zhang#*, Shuhong Dong #, Zhongxin Li, Li Lu, Su Zhang, Xue Chen，Xiaobo Cen, Yongjie Wu*, Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin, Journal of Translational Medicine, 2015, 13:349-349

9. Xuexi Wang, Li Lu, Chunli Song, Weina Qian, Shengyan Zhang, Yingqi Zhang, Yongjie Wu*, Comparative pharmacokinetics of a tumour-targeting therapy candidate rh-IFNa2a–NGR with rh-IFNa2a administered intravenously in mice and rats,  The Journal of Pharmacy and Pharmacology, 2013, 65:574-581